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Neuroinflammation as a cause of depression

Ketamine can help reverse Neuroinflammation – this may decrease depression

Evidence of Neuroinflammation in Fibromyalgia

Previous research has shown elevated levels of proinflammatory cytokines in the cerebrospinal fluid of patients with fibromyalgia. PET also has identified neuroinflammation in patients with a clinically similar condition, chronic fatigue syndrome. The study below provides direct evidence of neuroinflammation and suggests that neuroinflammation is a target for therapy. Low dose Naltrexone reduced glial activation in the brain and improved symptoms in small controlled studies of fibromyalgia patients. The current study indicates that smoldering and potentially treatable neuroinflammation is present in the brains of patients with fibromyalgia.


Albrecht DS et al. Brain glial activation in fibromyalgia – A multi-site positron emission tomography investigation. Brain Behav Immun 2019 Jan; 75:72. (

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